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Adrian J L Clark Selected Research

Type 2 Melanocortin Receptor

1/2004Constitutive activation of the human ACTH receptor resulting from a synergistic interaction between two naturally occurring missense mutations in the MC2R gene.
12/2002Impaired desensitization of a mutant adrenocorticotropin receptor associated with apparent constitutive activity.

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Adrian J L Clark Research Topics

Disease

6Achalasia Addisonianism Alacrimia syndrome
12/2009 - 12/2002
4Familial Glucocorticoid Deficiency 1
08/2014 - 12/2006
3Adrenal Insufficiency (Adrenal Gland Hypofunction)
07/2019 - 08/2007
3Obesity
11/2013 - 03/2007
3Hypoglycemia (Reactive Hypoglycemia)
01/2011 - 02/2005
3Infections
10/2009 - 02/2005
2Hyperplasia
01/2015 - 05/2006
2Hyperpigmentation
10/2013 - 05/2012
2Hypertension (High Blood Pressure)
02/2010 - 03/2007
2Cushing Syndrome
05/2006 - 12/2002
1Body Weight (Weight, Body)
01/2016
1Autoimmune Polyendocrinopathies (Schmidt Syndrome)
01/2015
1Cerebral Palsy (Spastic Diplegia)
10/2013
1Asthma (Bronchial Asthma)
10/2013
1Septic Shock (Toxic Shock Syndrome)
10/2013
1Cyanosis
10/2013
1Hypotension (Low Blood Pressure)
10/2013
1Genomic Instability
03/2012
1Chronic Disease (Chronic Diseases)
08/2011
1Neurologic Manifestations (Neurological Manifestations)
12/2009
1Alacrima
12/2009
1Nervous System Diseases (Neurological Disorders)
12/2009
1Esophageal Achalasia (Megaesophagus)
12/2009
1Lipoid congenital adrenal hyperplasia
10/2009
1Inborn Genetic Diseases (Disease, Hereditary)
08/2007
1Addison Disease (Addison's Disease)
02/2007
1Adenoma (Adenomas)
05/2006
1Laron Syndrome (Syndrome, Laron)
02/2005
1Hypersensitivity (Allergy)
01/2004
1Glucose Intolerance
06/2003
1Type 2 Diabetes Mellitus (MODY)
06/2003
1Adrenoleukodystrophy (Adrenoleukodystrophy, X-Linked)
12/2002

Drug/Important Bio-Agent (IBA)

10GlucocorticoidsIBA
07/2019 - 05/2006
9Adrenocorticotropic Hormone (ACTH)FDA Link
08/2014 - 12/2002
4Hydrocortisone (Cortisol)FDA LinkGeneric
10/2013 - 02/2005
3Insulin-Like Growth Factor I (IGF-1)IBA
08/2011 - 02/2005
3Proteins (Proteins, Gene)FDA Link
12/2009 - 12/2002
3Corticotropin Receptors (ACTH Receptor)IBA
02/2007 - 12/2002
2Dexamethasone (Maxidex)FDA LinkGeneric
10/2013 - 02/2010
2ElectrolytesIBA
10/2013 - 01/2011
2SaltsIBA
03/2007 - 02/2007
2Type 2 Melanocortin ReceptorIBA
01/2004 - 12/2002
1MineralocorticoidsIBA
07/2019
1CatecholaminesIBA
07/2019
1Pro-Opiomelanocortin (Proopiomelanocortin)IBA
01/2016
1MelanocortinsIBA
11/2013
1Type 1 Melanocortin ReceptorIBA
05/2012
1Minichromosome Maintenance ProteinsIBA
03/2012
1Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)IBA
09/2011
1G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
09/2011
1MetyraponeFDA Link
02/2010
1ApoferritinsIBA
12/2009
1SteroidsIBA
10/2009
1Angiotensin Receptor AntagonistsIBA
03/2007
1Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
03/2007
1Somatotropin Receptors (Growth Hormone Receptor)IBA
02/2005
1Insulin-Like Growth Factor Binding Protein 3IBA
02/2005
1Growth Hormone (Somatotropin)IBA
02/2005
1GlucokinaseIBA
06/2003
1Glucose (Dextrose)FDA LinkGeneric
06/2003
1DNA (Deoxyribonucleic Acid)IBA
02/2003
1Biological ProductsIBA
02/2003
1Fatty Acids (Saturated Fatty Acids)IBA
12/2002

Therapy/Procedure

1Therapeutics
08/2007
1Protein-Restricted Diet (Diet, Protein Restricted)
03/2007